Paracetamol (acetaminophen) is one of the most popular
analgesic and antipyretic drugs. Paracetamol is available in different dosage
forms: tablet, capsules, drops, elixirs, suspensions and suppositories. Dosage
forms of paracetamol and its combinations with other drugs have been listed in
various pharmacopoeias. The combination of paracetamol with dipyrone is used asan antipyretic, analgesic and anti-inflammatory drug. Numerous methods have
been reported for the analysis of paracetamol and its combinations in pharmaceuticals
or in biological fluids. Paracetamol has been determined in combination with
other drugs using titrimetry, voltammetry, fluorimetry, colorimetry,
UV-spectrophotometry, quantitative thin-layer chromatography (TLC),
high-performance liquid chromatography (HPLC) and gas chromatography (GC) in
pharmaceutical preparations.
Effect of electrophilic and electrodotic groups on
the potentiometric titration of amides and other weak bases was studied.
Electrodotic groups enhance the potentiometric end point and electrophilicgroups depress it, sometimes to the extent that the compound is not titratable.
A combination of chloroform and acetic anhydride is a useful alternative medium
for the titration of weak bases. A potentiometric method for determination of p-acetamidophenol
was reported.
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