Famotidine (FAM), 3-[({2-[(diaminomethylidene) amino]-1,3- thiazol-4-yl}methyl)sulfanyl]-N’- sulfamoylpropanimidamide, is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. The chemical formula of FAM together with the atomic numbering . Due to the presence of amino, amido and thioether groups in its structure, this drug possesses chelating properties and may interact very effectively with the essential metal ions present in blood plasma and different tissues. In the crystalline state, famotidine has two polymorphic forms that differ by arrangement of intermolecular hydrogen bonds.
Several binary FAM complexes containing divalent transition metal ions have been synthesized in solution as well as in the solid state. Determination of stability constant of complexes with drugs are useful to know the proper dose of drug and their effect with all other components of blood stream as well as to measure the strength of metal ligand bonds. The complexes of drugs have higher efficacy than parent drugs. In the present investigation, the stability constants of zinc (II) complexes with famotidine(FAM) and peptides (L) were studied in detail by potentiometric titration method in aqueous solutions at 25°C and I=0.10 mol/L NaNO3. Species distribution over a range of pH of the complexes in solution was evaluated.
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