Synthesis, Characterization and Biological Approach of N’-(3-(Hydroxy Imino) Butan-2-ylidene)-2-Oxo-2H-Chromene-3-Carbohydrazide Complexes

Coumarin family considered an essential heterocyclic compounds which belong to benzopyrones family that contains of phenyl ring fused with a pyrone ring. Coumarin classified into six groups count on chemical structure of compounds and these group are simple (coumarins, bi coumarins, phenyl coumarins, pyrano coumarins, furano coumarins and dihydrofurano coumarins)Coumarin mainly existed in plant kingdom such as (leaves, roots, stems and fruits). Besides, they found in different oils as ‘’lavender oil, cinnamon bark, oil and cassia oil’’.

Moreover, coumarin derivatives have changed uses such as ‘’optical brightening agents, laser dyes, cosmetic industry agrochemical industries and food additives’’. Furthermore, Coumarin derivatives have important biological activity as antibacterial, antifungal, anti-oxidant, anti-allergic, antiinflammatory, anti-thrombotic, hepatoprotective, anti-viral, anticarcinogenic activities. So, this study involved the biological estimation of N’-(3-(hydroxyimino) butan-2-ylidene)-2-oxo-2Hchromene- 3-carbohydrazide (H2L) and its metal complexes.

Synthesis and Investigation of New Different Pyrimidine-Thiones

The need for the new researches for raising the efficiency of in the development of the petrochemical and medical industry is noticeable. Especially, there is a specific fundamental and applicable issue in science that the approach on a scientific direction in their solution does not justify itself and is not achieved satisfactory results for many years. The need for a complex scientific approach arises for such issues and the most successful scientific results of recent years are found in the research of the intersection of science with the multidisciplinary approach. 

From this point of view, as a result of the most recent studies conducted in the Institute of Chemistry of Additives of the Azerbaijan National Academy of Sciences, it was determined that, biocide additives synthesized at the institute shows biological (physiological) activity in other areas too, in addition to protect the oil products from the microbiological damage. For instance, amino ethanol and some derivatives of amino alcohols synthesized by the employees of Institute shows the properties of anesthetic and terminal anesthesia for the mucous membranes of the eye. The studies were conducted at the first Moscow State Medical Institute named after Sechenov IM. These substances are 7 times greater compared to the widely-used “xycain”, according to its activity.