The
importance of selenium (Se) in human is well established, and its deficiency
has caused serious diseases such as cancer and heart disease. Around 25
selenoproteins contain selenium as important element, which are commonly known
as selenocysteine. In addition, research on selenium has gained significant
attention due to its important role in antioxidant selenoproteins for
protection against oxidative stress initiated by excess reactive nitrogen
species (RNS) and reactive oxygen species (ROS). In selenocysteins, selenium
metal functions as redox centre in various processes, which includes thereduction of nucleotides in DNA synthesis through selenoenzyme and thioredoxinreductase; and production of active thyroid hormone pre-cursor from
selenium-dependent iodothyronine deiodinases.
Furthermore, the bioavailability
of selenium plays a crucial role in its anticancer and antioxidant activities.
It is reported that the particles with crystallite size of nanometre range
exhibit better bioavailability and low toxicity as compared to particles withlarge crystallite size. After considering the vast importance of selenium as
nutrient in human body, authors wish to investigate an economically safe
approach that could be beneficial to modify the physical and thermal properties
of selenium powder.
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