Anti-diabetes and Anti-inflammatory Activities of Phenolic Glycosides from Liparis odorata

Liparisodorata (Willd.)Lindl., belonging to the Orchid family, is an herbaceous plant widely distributed in southern China, and usually used to inhibit inflammation and reduce lipid in Jiangxi province folk medicine in China. Throughour continuous interest in the chemical andbiologically active constituents of this plant, five new phenolic glycosides were isolated and their structures elucidated through extensive spectroscopic analyses, as well as literature comparisons. In addition, one known compound was isolated and identified as 4-allyl-2,6-dimethoxyphenol glucoside

To the best of our knowledge, obesity therapy using phenolic glycoside derivatives has not been studied yet, and we here reportthe anti-diabetes effects against protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase enzymes forall the isolated compounds. PTP1B plays a critical role as a key negative regulator of theinsulin and leptin signaling pathways, thereby regulating glucose homeostasis and body weight, respectively, while α-glucosidase inhibition is critical for the early treatment of diabetes mellitus. Therefore, effective inhibition of both enzymesis a potential therapy for both type 2 diabetes mellitus and obesity.