Diclofenac
sodium, the first phenylacetic acid derivative developed as an
anti-inflammatory agent, is an inhibitor of cyclooxygenase extensively used for
its analgesic, antipyretic and antiinflammatory activities. It is a potentnon-steroidal anti-inflammatory drug, extensively used for the treatment ofactive rheumatoid arthritis and osteoarthritis, ankylosing spondylitis,
non-articular rheumatism and sport injuries. DS is one of the most consumed
drugs by the population in DR Congo.
The literature reports few studies on the
effect of humidity and temperature on the stability of DS.The purpose of this study was to evaluate thequality of three generics of 50 mg DS tablets manufactured in DR Congo in
comparison to the original formulation Voltarène® from Novartis Pharma. Drug
content and drug release were determined at the time of their collection and at
3 and 6 months during their storage under the accelerated-aging conditions of
temperature and relative humidity (RH) recommended by the WHO for climatic zone
IVB (40°C/75% RH)
No comments:
Post a Comment