Synthesis and Anticancer Activity of Some Novel Fused Nicotinonitrile Derivatives

Pyridine nucleus and their fused heterocyclic systems have attracted a great deal of interest over the years . Furthermore, pyridine is one of the most popular N-heteroaromatics incorporated into the structure of many pharmaceuticals. Among these, cyanopyridines (nicotinonitriles) with different alkyl and arylgroups were found to have antihypertensive antiinflammatory, analgesic, antipyretic properties antimicrobial, cardiotonic, anticancer activity as well as 1KK-b inhibitor properties. 

Additionally, there is much interest in the anticancer activity of these compounds owing to different types of biological targets they might interfere with for this effect to occur e.g., PDE3, PIM1 Kinase, and Survivin protein. In view of the previous applications andcontinuation of our previous work on chemistry and pharmaceutical activity on nicotinonitrile derivatives we aim to use 4-methyl-2,6-dioxo-1-phenyl-1,2,5,6-tetrahydropyridine-3- carbonitrile as building blocks for the synthesis of some new family of fused heterocyclic compounds incorporating pyridine moiety with the hope to possess better anticancer activity.